Morphometry of nuclei of the benign and malignant prostatic lesions was performed to study the relationship between nuclear size and shape and the prognosis of prostatic adenocarcinoma. Fifty one cases of prostatic adenocarcinoma and
13
cases of benign prostatic hyperplasia were included to evaluate area, perimeter, Dmax, Dmin, and 5 form factors of the nuclei by image analyzer(Zeiss lbas 2000) using hematoxylin-eosin stained slides. All analytic factors of nuclear size and
shape
were significantly different between benign lesions and adenocarcinomas, Increased nuclear size was associated with nuclear irregularity, presence of metastasis, advanced clinical stage, and high Gleason's grade and score of
prostatic
adenocarcinoma. On kaplan-Meier method, survival was decreased with older age, no hormonal treatment, stage D. high Gleason's grade and stage as well as with larger size and irregular shape of the nuclei. In conclusion, morphometry or
nuclei
of the prostate can be a helpful tool to differentiate between benign and malignant lesions. Nuclear morphology is thought to be associated with prognosis of prostatic adenocarcinoma.
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